Disease specific iPS cell line derived from a patient : Muscular dystrophy, Duchenne type. Correction of the dystrophin gene. HPS0383, HPS0385, HPS0386 and HPS0387 were derived from the same patient.
To restore Dystrophin gene reading frame, one base was introduced to exon 45 by using TALEN.
疾患特異的iPS細胞株。デュシェンヌ型筋ジストロフィー患者由来。Dystrophin遺伝子を修復。HPS0383、HPS0385、HPS0386、HPS0387と同一人由来。エピソーマルベクターにより6因子（Oct3/4, Sox2, Klf4, L-Myc, Lin28, p53 shRNA）を導入して樹立。<a href='http://cell.brc.riken.jp/ja/manual/vitrification' target="_blank">ガラス化法（Vitrification法）</a>保存。
HPS0384
疾患特異的iPS細胞株。デュシェンヌ型筋ジストロフィー患者由来。Dystrophin遺伝子を修復。HPS0383、HPS0385、HPS0386、HPS0387と同一人由来。エピソーマルベクターにより6因子（Oct3/4, Sox2, Klf4, L-Myc, Lin28, p53 shRNA）を導入して樹立。<a href='https://cell.brc.riken.jp/ja/manual/vitrification' target="_blank">ガラス化法（Vitrification法）</a>保存。
<a href="http://www.cira.kyoto-u.ac.jp/" target="_blank">http://www.cira.kyoto-u.ac.jp/</a>
1) The BIOLOGICAL RESOURCE must be used for academic research purpose conducted by RECIPIENT who belongs to a not-for profit academic organization (i.e. a university or another institution of higher education or any non-profit scientific or educational organization, including government agencies) . 2) The RECIPIENT agrees to obtain the prior written approval of the distribution from the APPROVER. 3) Contact Us : <a href="mailto:cellips.brc@riken.jp?subject=Disease specific iPS cell line&">RIKEN Cell Bank</a>
CiRA00111-IF-D28
Disease specific iPS cell line derived from a patient : Muscular dystrophy, Duchenne type. Correction of the dystrophin gene. HPS0383, HPS0385, HPS0386 and HPS0387 were derived from the same patient. Order Form (C-0042, C-0057, C-0007).
DYSTROPHIN遺伝子の読み枠を修復するために、TALENを用いてエクソン45に1 塩基挿入。
1) 非営利の団体に所属する利用者による学術研究での使用に限る。 2) 利用者は、事前に承諾者から承諾を得ること。 3) 先ずは、<a href="mailto:cellips.brc@riken.jp?subject=Disease specific iPS cell line 問い合わせ&">理研細胞バンク</a>にお問い合わせください 。